Sheldon CheskesMD CCFP (EM) FCFP
Associate Professor
DFCM - Emergency Medicine Division

Location

Sunnybrook Health Sciences Centre
77 Browns Line
Suite 100
Toronto
ON, M8W 3S2

Research Interests

Emergency Medicine, Resuscitation Science, Experimental (e.g., RCTs), Observational (e.g., cohort, case-control), Case Studies, Quantitative Data Analysis

Accepting

Graduate Students, Other, Summer Students, Volunteers

-Associate Professor, Emergency Medicine, Family and Community Medicine, Faculty of Medicine, University of Toronto, Ontario, Canada
-Scientist, Keenan Research Institute, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
-Medical Director, Regions of Halton and Peel, Sunnybrook Centre for Prehospital Medicine, Sunnybrook Health Sciences Centre
-Co Principal Investigator, Toronto Regional Rescuenet, Resuscitation Outcomes Consortium, St. Michael’s Hospital
-Courtesy Staff, Department of Emergency Medicine, Sunnybrook Health Sciences Centre
-Active Staff, Department of Family Medicine, William Osler Health Centre, Brampton Civic Hospital
-Medical Director, Spectrum Patient Care Services, Ontario, Canada
-Medical Director, Mississauga Fire & Emergency Services
-Medical Director, Caledon Fire and Emergency Services
-Medical Director, Brampton Fire and Emergency Services

 

Research/Teaching

Research Synopsis:

Dr. Cheskes research interests lay in the area of resuscitation science particularly the area of cardiac arrest resuscitation. He has a particular interest in CPR quality and its impact on cardiac arrest survival. He as well has interests in STEMI systems of care as well as pre-hospital airway management. Dr. Cheskes currently is a co principal investigator in studies exploring the impact of early prehospital treatment of sepsis (PITSTOP trial) as well as the impact of remote ischemic conditioning on clinical outcomes from STEMI (FIRST study). Finally innovative techniques in the treatment of refractory ventricular fibrillation (double sequential external defibrillaiton, ECMO) are an area of particular interest.

Grants:

PEER-REVIEWED GRANTS
FUNDED
2016 Jul - 2017 Dec    Principal Investigator. FIRST Study- Field implementation of the AutoRiC device in ST segment elevation myocardial infarction. HTX. REACH Grant. REACH Grant. Collaborator(s): Richard Verbeek, Paul Dorian, Dennis Ko, Madhu Natarajan, Dominic Raco, Bob Singh, Laurie Morrison, Michelle Welsford. 710,000 CAD. [Grants]
Research exploring the impact of remote ischemic conditioning for patients with STEMI.


2015 Jul - 2020 Jul    Co-Investigator. CanROC- Canadian Resuscitation Outcomes Consortium:Toward a National Resuscitation Clinical Research Network. Canadian Institutes of Health Research (CIHR). ICRH Community Development Grant. PI: Morrison, Laurie. Collaborator(s): Stiell, Ian, Christenson, Jim, Dorian, Paul, Vaillancourt,Christian. 1,500,000 CAD. [Grants]
Development of a Canadian Resuscitation research network based on the lessons learned from ROC over the last 10  years. Development of a national cardiac arrest registry as well as the opportunity to do interventional and observational research in cardiac arrest, trauma, and pediatric resuscitation.

2015 Jul - 2020 Jul    Co-Investigator. CanROC- Canadian Resuscitation Outcomes Consortium:Toward a National Resuscitation Clinical Research Network. Heart and Stroke Foundation of Canada (HSFC). ICRH Community Development Grant. PI: Morrison, Laurie. Collaborator(s): Stiell, Ian, Christenson, Jim, Dorian, Paul, Vaillancourt,Christian. 1,500,000 CAD. [Grants]
Development of a Canadian Resuscitation research network based on the lessons learned from ROC over the last 10  years. Development of a national cardiac arrest registry as well as the opportunity to do interventional and observational research in cardiac arrest, trauma, and pediatric resuscitation.

2015 Jun - 2018    Co-Investigator. A Pragmatic Strategy Empowering Paramedics to Assess Low‐Risk Trauma Patients with the Canadian C‐Spine Rule and Selectively Transport them Without Immobilization. Ontario SPOR SUPPORT Unit. IMPACT Award. PI: Vaillancourt , Christian. 1,456,990 CAD. [Grants]
This trial will look at decreasing the use of C spine immobilization by paramedics in pre-hospital care.

2015 - 2020    Co-Principal Investigator. Paramedic Initiated Treatment of Sepsis Trial in Out-of-hospital Patients (PITSTOP). Canadian Institutes of Health Research (CIHR). Heatlh Services and Policy Research. 342603. PI: Scales Damon. Collaborator(s): Dr. S. Cheskes Mr. I. Drennan Dr. T. Mazzulli Dr. A. Morris, Dr. L. Morrison Dr. G. Rubenfeld Dr. C. Seymour Dr. P. Verbeek. 900,555 CAD. [Grants]
A randomized controlled trial investigating the impact of paramedic identification and treatment of sepsis in the prehospital care field.

2014 Nov - 2015 Nov    Co-Principal Investigator and Supervising Investigator. Finding the Sickest Patients: Validation of a Prehospital Sepsis Screening Tool. Ontario Paramedic Research Consortium. PI: Cheskes, S. Collaborator(s): Mausz J, Tavares W, Turner L, MacCalman, Alvarez R. 3,865 CAD. [Grants]

2014 Oct - 2017 Sep    Co-Investigator. The Frontier Trial - Field Randomization of NA-1 Treatment In Early Responders. NoNO Inc. PI: Morrison, Laurie. Collaborator(s): Morrison L, Benavente O, Casaubon L, Cheskes S, Christenson J, Demchuck A, Dick W, Goyal M, Hill M, Martin R, Mehdirata M, Perez Y, Selchen D, Swartz R, Tymianski M, Verbeek PR. 1,600,000 CAD. [Industrial Grants]

2014 Oct - 2017 Sep    Co-Investigator. The Frontier Trial - Field Randomization of NA-1 Treatment In Early Responders. Brain Canada. PI: Morrison, Laurie. Collaborator(s): Morrison L, Benavente O, Casaubon L, Cheskes S, Christenson J, Demchuck A, Dick W, Goyal M, Hill M, Martin R, Mehdirata M, Perez Y, Selchen D, Swartz R, Tymianski M, Verbeek PR. 6,578,920 CAD. [Grants]

2014    Principal Investigator. The association between chest compression release velocity and clinical outcomes from out-of-hospital cardiac arrest. ZOLL Medical Corporation. Collaborator(s): Cheskes S, Common M, Byers A, Zhan C, Morrison L. 15,000 CAD. [Industrial Grants]

2013 Sep - 2016 Sep    Co-Investigator. Assessing and improving the quality of care of patients with out-of-hospital cardiac arrest. Canadian Institutes of Health Research (CIHR). Operating Grant. PI: Ko, D. Collaborator(s): Ko D, Austin P, Morrison L, Stukel T, Wijeysundera H, Cheskes S, Rac V, Tu J, Dorian P, Scales D, Verbeek R. 443,022 CAD. [Grants]

2012 Jan - 2013 Jun    Principal Investigator. Does prehospital CPAP impact the treatment and mortality of acute respiratory emergencies? Ontario Paramedic Research Consortium. Collaborator(s): Cheskes S, Turner L, Thomson S, Aljerian N, Summers J. 2,500 CAD. [Grants]

2011 Oct - 2015 Oct    Co-Principal Investigator. The ICE-PACS randomized control trial. A trial investigating the ability of pre hospital hypothermia and its impact on in hospital cooling rates. Canadian Institutes of Health Research (CIHR). Operating Grant. PI: Scales D. Collaborator(s): Scales D, Morrison LJ, Brooks S, Thorpe K, Mamdani M, Dainty K, Perreira T, Cheskes S, Craig A, Verbeek R, Darling S. 945,275 CAD. [Grants]


2010 - 2016    Co-Principal Investigator. From Bench to Bedside to Curbside. Clinical Research Consortium to improve Resuscitation Outcomes. Heart and Stroke Foundation of Canada (HSFC). PI: Morrison, Laurie. Collaborator(s): Nathens A, Slutsky AS, Dorian P. 1,500,000 CAD. [Grants]

2010 - 2016    Co-Principal Investigator. Resuscitation Outcomes Consortium Core Training Grant. National Institutes of Health & Heart and Stroke Foundation of Canada & Canadian Institute of Health Research. PI: Morrison, Laurie. Collaborator(s): Nathens A, Slutsky AS, Dorian P. 335,000 USD. [Grants]

2010 - 2016    Co-Principal Investigator. From Bench to Bedside to Curbside. Clinical Research Consortium to improve Resuscitation Outcomes. National Institutes of Health (NIH) (USA). PI: Morrison, Laurie. Collaborator(s): Nathens A, Slutsky AS, Dorian P. 648,000 USD. [Grants]

2009 - 2016    Co-Principal Investigator. From Bench to Bedside to Curbside. Clinical Research Consortium to improve Resuscitation Outcomes. Canadian Institutes of Health Research (CIHR). Institute of Circulatory and Respiratory Health (ICRH). PI: Morrison, Laurie. Collaborator(s): Nathens A, Slutsky AS, Dorian P. 1,057,000 CAD. [Grants]

Publications and Awards

Recent Publications

1. Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW, Christenson J, Egan D, Ornato JP,  Weisfeldt ML, Stiell IG, Idris AH, Aufderheide TP, Dunford JV, Colella MR, Vilke GM, Brienza AM, Desvigne‑Nickens P, Gray PC,Gray R, Seals N, Straight R, and Dorian P, for the Resuscitation Outcomes Consortium Investigators*. Amiodarone, Lidocaine, or Placebo  in Out-of-Hospital Cardiac Arrest. New England Journal of Medicine. 2016 Apr 4.
2. Drennan IR, Strum RP, Byers A, Buick JE, Lin S, Cheskes S, Hu S, Morrison LJ. Out-of-Hospital Cardiac Arrests in High Rise Buildings: Delays to Patient Care and Survival. Canadian Medical Association Journal _CMAJ. 2016 Jan 18. 
3. Nichol G; Callaway C; Isaacs M; Vaillancourt C, Sopko G; Idris A; Ornato J; Richardson JD; Cheskes S; Leroux B; Kudenchuk P; Stephens SW; Egan D; Weisfeldt M; Straight R; Condle JP; May S; Schmicker RH ; Morrison LJ; Rea T; Aufderheide T; Stiell I; Christenson J  and the ROC Investigators. Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine. 2015 Dec 3;373:2203-2214. 
4. Cheskes S, Schmicker RH, Rea T, Powell J, Drennan IR, Kudenchuk P, Vaillancourt C, Conway W, Stiell I, Stub D, Davis D, Alexander N, Christenson J,  and the Resuscitation Outcomes Consortium (ROC) investigators. Chest compression fraction: a time dependent variable of survival in shockable out-of-hospital cardiac arrest. Resuscitation. 2015 Dec;97:129-135. 
5. Cheskes S, Hillier M, Zahn C, Byers A, Verbeek PR, Morrison LJ. The association between manual mode defibrillation, pre-shock pause duration and appropriate shock delivery when employed by basic life support paramedics during out-of-hospital cardiac arrest. Resuscitation. 2015 Mar 13;90:61-66. 
6. Cheskes S, Byers A, Zahn C, Silver AM, Morrison LJ. The impact of compression release velocity on outcomes from out-of-hospital cardiac arrest. Resuscitation. 2015 Jan;86:38-43. Available from: http://dx.doi.org/10.1016/j.resuscitation.2014.10.020. 
7. Cheskes S, Schmiker RH, Verbeek PR, Salcido DD, Brown SP, Brooks S, Menegazzi JJ, Vaillancourt C, Powell J, May S, Berg RA, Sell R, Idris A, Kampp M, Schmidt T, Christenson J and the Resuscitation Outcomes Consortium Investigators. The impact of peri-shock pause on survival from out-of-hospital shockable cardiac arrest during the ROC PRIMED trial. Resuscitation. 2014;85(3):336-342.
8. Cheskes S, Common MR, Byers A, Zahn C, Morrison LJ. Compressions during defibrillator charging shortens shock pause duration and improves chest compression fraction during shockable out-of-hospital cardiac arrest. Resuscitation. 2014;85(7):1007-1011. 
9. Cheskes S, Turner L, Thomson S, Aljerian N. Does Prehospital CPAP impact the rate of intubation and mortality from acute respiratory emergencies. Prehospital Emergency Care. 2013;17(4):435-441.
10. Cheskes S, Thomson S, Turner L. Feasibility of Continuous Positive Airway Pressure by Primary Care Paramedics. Prehospital Emergency Care. 2012;16(4):535-540. 
11. Stiell I, Nichol G, Leroux B, Rea T, Ornato J, Powell J, Christenson J, Callaway C, Kudenchuk P, Aufderheide T, Idris A, Daya M, Wang H, Morrison L, Davis D, Andrusiek D, Stephens S, Cheskes S, Schmicker R, Fowler R, Vaillancourt C, Hostler D, Zive D, Pirrallo R, Vilke G, Sopko G, Weisfeldt M, for Resuscitation Outcomes Consortium (ROC) Investigators. Early vs. Later Rhythm Analysis in Patients with Out-of-Hospital Cardiac Arrest. NEJM. 2011;365:787-797. 
12. Cheskes S, Turner L, Froggett R, Thomson S, Popov D, Huiskamp M, Sage G, Watson R, Verbeek R. Paramedic contact to balloon in less than 90 minutes: a successful strategy for STEMI bypass to Primary PCI in a Canadian Emergency Medical System. Prehospital Emergency Care. 2011;15:1-8.
13. Cheskes S, Schmicker RH, Christenson J, Menegazzi J, Rea T, Powell J, May J, Salcido D,  Olsufka M, Pennington S, Simonini J, Allendes F, Edelson D, Stiell I, Berg R, Van Ottingham L, Idris A, Sell R, Bigham B, Morrison L, and the ROC investigators. Peri-shock pause: An independent predictor of survival from out-of-hospital shockable cardiac arrest. Circulation. 2011;124:58-66. 

 

Honours and Awards

HONOURS AND CAREER AWARDS
Distinctions and Research Awards
INTERNATIONAL
-The Abigail and Gary Conrad Emergency Medicine Research Award, U Penn (university of Pennsylvania), Philadelphia, Pennsylvania, United States. (Research Award, Specialty: Emergency Medicine)
-“Top 12 papers of 2015 to impact clinical practice”, New England Journal of Medicine. (Research Award)
Trial of Continuous or Interrupted Chest Compressions during CPR.
-Best cardiac arrest presentation winner, NAEMSP. (Distinction)
The impact of peri-shock pause on survival from out-of- hospital shockable cardiac arrest during the Resuscitation Outcomes Consortium PRIMED trial. 
-Best scientific presentation winner, NAEMSP. (Distinction)
The impact of peri-shock pause on survival from out-of- hospital shockable cardiac arrest during the Resuscitation Outcomes Consortium PRIMED trial. 
-“Best poster presentation” winner, NAEMSP. (Distinction)
“Does Prehospital CPAP impact the mortality and morbidity of acute respiratory emergencies”. 2013 

NATIONAL

-“Top 4 in Canadian Emergency medicine Research”, CAEP. (Research Award)
The impact of peri-shock pause on survival from out-of-hospital shockable cardiac arrest during the Resuscitation Outcomes Consortium PRIMED trial. 
Nominated

PROVINCIAL / REGIONAL
Received

-Department of Family and Community Medicine Research Excellence Award (Senior), University of Toronto. (Research Award, Specialty: Emergency Medicine)
-Service Recognition Award for Medical Oversight in EMS (20 years), Ontario Base Hospital Group. (Distinction)
-Lifetime Achievement Award, Ontario Paramedic Association. (Distinction)
Awarded for Excellence in Prehospital Care.

LOCAL

-Hospital Achievement Award, Emergency Medicine Service, William Osler Health System, Brampton Memorial Hospital Campus. (Distinction)
-Dr. Sheldon Cheskes Bursary Award for Excellence in Paramedic Education, RESCU, St. Michael’s Hospital, University of Toronto. (Distinction)
To be awarded to a paramedic on a yearly basis showing excellence in prehospital research and education.
-Quality Award of Excellence, Trillium Health Centre. (Distinction)
ST Elevation Myocardial Infarction: Quality Care Achieved Through Regional Partnerships.
-Hospital Achievement Award, Peel Memorial Hospital. (Distinction)
- Physician Recognition Award Education Committee, Peel Memorial Hospital. (Distinction)

Teaching and Education Awards

LOCAL

-Hospital Achievement Award, Medical Education, William Osler Health Centre, Brampton Memorial Hospital Campus. (Continuing Education)

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